名称：Amyloid-β (phospho Thr743)

别名：APP; A4; AD1; Amyloid beta A4 protein; ABPP; APPI; APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II

Pathway：Notch signaling pathway

Modified：Phosphorylated

Targets：FDA approved drug target related

描述

amyloid beta precursor protein(APP) Homo sapiens This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014],

Specification

Entrez GeneID：351

Swissprot：P05067

Gene Accession：Swiss Prot:P05067
GeneID:351

WB Predicted band size：140kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：The antiserum was produced against synthesized peptide derived from human Amyloid beta A4 around the phosphorylation site of Thr743/668. AA range:711-760

Formulation：Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

Application

Application：WB,IHC,IF

WB：1/500 - 1/2000

IHC：1/100 - 1/300

ICC：1/200 - 1/1000

ELISA：1/10000

宿主：Rabbit