名称：PIP5K

别名：1-phosphatidylinositol-4-phosphate 5-kinase; EC 2.7.1.68; FYV1; FYVE finger-containing phosphoinositide kinase; KIAA0981

Targets：Disease

描述

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.Ota T., Nat. Genet. 36:40-45(2004).Sbrissa D., J. Biol. Chem. 277:6073-6079(2002).Brill L.M., Anal. Chem. 76:2763-2772(2004).

Specification

Entrez GeneID：200576;

Swissprot：Q9Y2I7

Gene Accession：Swiss-Prot: Q9Y2I7NCBI Gene ID: 200576

WB Predicted band size：237kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse

免疫原：Synthesized peptide derived from internal of human PIP5K.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IF

WB：1/500-1/3000

ICC：1/100-1/500

宿主：Rabbit