名称：ATF-2 (Ab-472)

别名：Activating 2; ATF2; cAMP response element binding protein CRE- BP1; CREB2; CREBP1

Pathway：TGF-beta signaling pathway

Pathway：PI3K-Akt signaling pathway

Pathway：MAPK signaling pathway

描述

Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.Maekawa T., EMBO J. 8:2023-2028(1989).Yang L., J. Immunol. 158:2522-2525(1997).Hillier L.W., Nature 434:724-731(2005).

Specification

Entrez GeneID：1386;

Swissprot：P15336

Gene Accession：Swiss-Prot: P15336NCBI Gene ID: 1386

WB Predicted band size：70kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Synthesized non-phosphopeptide derived from human ATF-2 around the phosphorylation site of serine 472 (A-L-S(p)-Q-I).

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：1/500-1/3000

宿主：Rabbit