名称：IKK a(Ab-23)

别名：I kappa-B kinase alpha; I-kappa-B kinase 1; IKK-A; IKK-alpha; IKK1

Pathway：PI3K-Akt signaling pathway

Pathway：MAPK signaling pathway

描述

Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.

文献

Yuan ZQ, et al.(2002)J Biol Chem; 277(33): 29973-82.Ozes ON, et al. (1999)Nature; 401(6748): 82-5.

Specification

Entrez GeneID：1147;

Swissprot：O15111

Gene Accession：Swiss-Prot: O15111NCBI Protein: NP_001269.3

WB Predicted band size：85kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around aa.21~25 (L-G-T-G-G) derived from Human IKK a.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC

WB：1/500-1/1000

IHC：1/50-1/100

宿主：Rabbit