名称：AMPKα1/AMPKα2 (Ab-183/172)

别名：AMPK, AMPKa1

Pathway：Wnt signaling pathway

Pathway：PI3K-Akt signaling pathway

Targets：FDA approved drug target related

描述

Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.

文献

Hurley RL, et al. (2005) J Biol Chem. Aug 12; 280(32): 29060-29066

Woods A, et al. (2003) Curr Biol. Nov 11; 13(22): 2004-2008

Nielsen JN, et al. (2003) J Appl Physiol. Feb; 94(2): 631-641

Da Silva Xavier G, et al. (2000) Proc Natl Acad Sci U S A. Apr 11; 97(8): 4023-4028.

Specification

Entrez GeneID：5562;

Swissprot：Q13131

Gene Accession：Swiss-Prot: Q13131NCBI Protein: NP_006242.5 NP_006243.2

WB Predicted band size：63kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around aa. 181~185/170~174 (L-R-T-S-C) derived from Human AMPKα1/AMPKα2.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit