名称：TPH2 (Ab-19)

别名：Neuronal tryptophan hydroxylase; NTPH; Tryptophan 5- monooxygenase 2;

Targets：Disease

描述

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.Bader M., Science 299:76-76(2003).Gibbs R.A., Nature 440:346-351(2006).Pandey A., Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).

Specification

Entrez GeneID：121278;

Swissprot：Q8IWU9

Gene Accession：Swiss-Prot: Q8IWU9NCBI Gene ID: 121278

WB Predicted band size：56kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Synthesized non-phosphopeptide derived from human TPH2 around the phosphorylation site of serine 19 (G-FI-S(p)-L-D).

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：1/500-1/3000

宿主：Rabbit