名称：PKR(Ab-446)

别名：ADRB2; E2AK2; EIF2AK2; EIF2aK; PRKR

Targets：Disease

描述

Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.

文献

Abujiang Pataer, et,al. (2002) Cancer Res ; 62: 2239.K. D. Ryman, et,al. (2005) J. Virol ; 79: 1487 - 1499.Susana Guerra, et,al. (2006) J. Biol. Chem ; 281: 18734 - 18745.

Specification

Entrez GeneID：5610;

Swissprot：P19525

Gene Accession：Swiss-Prot: P19525 NCBI Protein: NP_001129123.1

WB Predicted band size：68kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Rat

免疫原：Peptide sequence around aa.444~448 (K-R-T-R-S) derived from Human PKR.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit