名称：MAP2K7 (Ab-271)

别名：EC 2.7.11.25; kinase TAK1; M3K7; MAP3K7; Mitogen-activated protein kinase kinase kinase 7

Pathway：TGF-beta signaling pathway

Pathway：MAPK signaling pathway

Targets：Disease

描述

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.Sakurai H., Biochem. Biophys. Res. Commun. 243:545-549(1998).Mungall A.J., Nature 425:805-811(2003).The MGC Project Team; Genome Res. 14:2121-2127(2004).

Specification

Entrez GeneID：6885;

Swissprot：O43318

Gene Accession：Swiss-Prot: O43318NCBI Gene ID: 5609

WB Predicted band size：60kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse

免疫原：Synthesized non-phosphopeptide derived from human MAP2K7 around the phosphorylation site of serine 271 (V-D-S(p)-K-A).

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：1/500-1/3000

宿主：Rabbit