名称：Bax (Ab-167)

别名：Apoptosis regulator BAX; membrane isoform alpha; BAXA; Bcl2-associated X protein;

Pathway：TGF-beta signaling pathway

描述

Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.Oltvai Z.N., Cell 74:609-619(1993).Cuddeback S.M., J. Biol. Chem. 276:20559-20565(2001).Guo B., Nature 423:456-461(2003)

Specification

Entrez GeneID：581;

Swissprot：Q07812

Gene Accession：Swiss-Prot: Q07812NCBI Gene ID: 581

WB Predicted band size：21kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse

免疫原：Synthesized non-phosphopeptide derived from human Bax around the phosphorylation site of threonine 167 (F-G-T(p)-P-T).

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IF

WB：1/500-1/3000

ICC：1/100-1/500

宿主：Rabbit