名称：IFIH1

别名：Interferon-induced helicase C domain-containing protein 1; EC 3.6.1.-; Interferon-induced with helicase C domain protein 1; Helicase with 2 CARD domains; Helicard

Targets：Disease

描述

Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.Kang D.-C., Proc. Natl. Acad. Sci. U.S.A. 99:637-642(2002).Cocude C., J. Gen. Virol. 84:3215-3225(2003).Ota T., Nat. Genet. 36:40-45(2004).

Specification

Entrez GeneID：64135;

Swissprot：Q9BYX4

Gene Accession：Swiss-Prot: Q9BYX4NCBI Gene ID: 64135

WB Predicted band size：120kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Synthesized peptide derived from C-terminal of human IFIH1.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：1/500-1/3000

宿主：Rabbit