名称：BMX

别名：BMX; BMX NON-receptor tyrosine kinase; Bone marrow kinase BMX; Cytoplasmic BMX; EC 2.7.10.2

描述

Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.Tamagnone L., Oncogene 9:3683-3688(1994).Qiu Y., Proc. Natl. Acad. Sci. U.S.A. 95:3644-3649(1998).Fuortes M., Thesis (1994), Cornell University, United States.

Specification

Entrez GeneID：660;

Swissprot：P51813

Gene Accession：Swiss-Prot: P51813NCBI Gene ID: 660

WB Predicted band size：75kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse

免疫原：Synthesized peptide derived from N-terminal of human BMX.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/3000

IHC：1/50-1/100

ICC：1/100-1/500

宿主：Rabbit