名称：ATG4B

别名：Cysteine protease ATG4B; EC 3.4.22.-; Autophagy-related protein 4 homolog B; hAPG4B; Autophagin-1

描述

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.Kabeya Y., J. Cell Sci. 117:2805-2812(2004).Marino G., J. Biol. Chem. 278:3671-3678(2003).Ota T.,Nat. Genet. 36:40-45(2004).

Specification

Entrez GeneID：23192;

Swissprot：Q9Y4P1

Gene Accession：Swiss-Prot: Q9Y4P1NCBI Gene ID: 23192

WB Predicted band size：44kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse

免疫原：Synthesized peptide derived from internal of human ATG4B.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC

WB：1/500-1/3000

IHC：1/50-1/100

宿主：Rabbit