名称：MEF2C (Ab-396)

别名：Myocyte enhancer factor 2C; Myocyte-specific enhancer factor 2C; Similar to MADS box transcription enhancer factor 2 polypeptide C;

Pathway：MAPK signaling pathway

Targets：Disease

描述

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture By similarity. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.Leifer D., Proc. Natl. Acad. Sci. U.S.A. 90:1546-1550(1993).McDermott J.C., Mol. Cell. Biol. 13:2564-2577(1993).Wang A.H., Mol. Cell. Biol. 19:7816-7827(1999).

Specification

Entrez GeneID：4208;

Swissprot：Q06413

Gene Accession：Swiss-Prot: Q06413NCBI Gene ID: 4208

WB Predicted band size：51kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse

免疫原：Synthesized non-phosphopeptide derived from human MEF2C around the phosphorylation site of serine 396 (P-V-S(p)-P-P).

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：1/500-1/3000

宿主：Rabbit