名称：PAK1/PAK2/PAK3(Ab-423/402/421)

别名：p21-activated kinase 1; PAK-1; p65-PAK; Alpha-PAK;

Pathway：MAPK signaling pathway

Targets：Disease

描述

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

文献

Parsons M, et al. (2005) Mol Cell Biol ; 25:1680-1695.Jung JH, et al. (2005) J Biol Chem; 280:40025-40031.Lampugnani MG, et al. (2002) Mol Biol Cell ; 13: 1175-1189Wang RA, et al. (2002) EMBO J; 21: 5437 - 5447.

Specification

Entrez GeneID：5058;

Swissprot：Q13153

Gene Accession：Swiss-Prot:Q13153Gene ID:5058

WB Predicted band size：61-67 (PAK2) 68-74 (PAK1/3)kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around aa.421~425/400~404/419~423 (R-S-T-M-V) derived from Human PAK1/PAK2/PAK3.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit