名称：MEK1/MEK2(Ab-217/221)

别名：ERK activator kinase 1/ERK activator kinase2; MAP kinase kinase 1/MAP kinase kinase 2; MAP2K1/MAP2K1; MAPK/ERK kinase 1/MAPK/ERK kinase 2; MAPKK 1/MAPKK 1

Pathway：TGF-beta signaling pathway

Pathway：PI3K-Akt signaling pathway

Pathway：mTOR signaling pathway

Pathway：MAPK signaling pathway

Pathway：Jak-STAT signaling pathway

Targets：Disease

描述

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.

文献

Shen R, et al. (2002) Mol Cell Biol; 22(10): 3230-3236Preisinger C, et al. (2005) EMBO J; 24(4): 753-765Laine P, et al. (2000) Biochem J; 349(Pt 1): 19-25Yaglom J, et al. (2003) Mol Cell Biol; 23(11): 3813-3824Dahan S, et al. (2002) Infect Immun; 70(5): 2304-2310

Specification

Entrez GeneID：5604;

Swissprot：Q02750

Gene Accession：Swiss-Prot: Q02750NCBI Protein: NP_002746.1 NP_109587.1

WB Predicted band size：45kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around aa.215~219/219~223 (I-D-S-M-A) derived from Human MEK1/MEK2.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit