名称：MKK3(Ab-189)

别名：MAP kinase kinase 3; MAP2K3; MAPK/ERK kinase 3; MAPKK 3; MEK3

Pathway：TGF-beta signaling pathway

Pathway：MAPK signaling pathway

Pathway：Jak-STAT signaling pathway

Targets：Disease

描述

MEK3 belongs to MAPKK family. This kinase is activated by mitogenic and environmental stress, and participates in the MAPK-mediated signaling cascade. It phosphorylates and thus activates p38. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of Ras oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of p38, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis.

文献

Wang W, et al. (2002) Mol Cell Biol ; 22(10): 3389-403.

Raingeaud J, et al. (1996) Mol Cell Biol; 16(3): 1247-55.

Specification

Entrez GeneID：5606;

Swissprot：P46734

Gene Accession：Swiss-Prot: P46734NCBI Protein: NP_002747.2

WB Predicted band size：40kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse

免疫原：Peptide sequence around aa.187~191 (V-D-S-V-A) derived from Human MKK3.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit