名称：XRCC3

别名：DNA-repair protein XRCC3; X-ray repair cross-complementing protein 3;

Targets：Disease

描述

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.Liu N., Mol. Cell 1:783-793(1998).Miller K.A., J. Biol. Chem. 277:8406-8411(2002).Liu N., Nucleic Acids Res. 30:1009-1015(2002).

Specification

Entrez GeneID：7517;

Swissprot：O43542

Gene Accession：Swiss-Prot: O43542NCBI Gene ID: 7517

WB Predicted band size：38kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Synthesized peptide derived from internal of human XRCC3.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：IHC,IF

IHC：1/50-1/100

ICC：1/100-1/500

宿主：Rabbit