名称：ILK (Ab-246)

别名：59 kDa serine/threonine protein kinase; EC 2.7.11.1; ILK-1; ILK1; Integrin-linked protein kinase

描述

Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.Hannigan G.E.,Nature 379:91-96(1996).Janji B.,Oncogene 19:3069-3077(2000).Tadic B.,Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.

Specification

Entrez GeneID：3611;

Swissprot：Q13418

Gene Accession：Swiss-Prot: Q13418NCBI Gene ID: 3611

WB Predicted band size：42kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Rat

免疫原：Synthesized non-phosphopeptide derived from human ILK around the phosphorylation site of serine 246 (I-F-S(p)-H-P).

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC

WB：1/500-1/3000

IHC：1/50-1/100

宿主：Rabbit