名称：CASP5

别名：Caspase-5, CASP-5, ICE(rel)-III, Protease ICH-3, Protease TY, Caspase-5 subunit p20, Caspase-5 subunit p10, CASP5, ICH3

描述

This gene encodes a member of the cysteine-aspartic acid

protease (caspase) family. Sequential activation of caspases plays

a central role in the execution-phase of cell apoptosis. Caspases

exist as inactive proenzymes which undergo proteolytic processing

at conserved aspartic residues to produce two subunits, large and

small, that dimerize to form the active enzyme. Overexpression of

the active form of this enzyme induces apoptosis in fibroblasts.

Max, a central component of the Myc/Max/Mad transcription

regulation network important for cell growth, differentiation, and

apoptosis, is cleaved by this protein; this process requires

Fas-mediated dephosphorylation of Max. The expression of this gene

is regulated by interferon-gamma and lipopolysaccharide.

Alternatively spliced transcript variants have been identified for

this gene.

Specification

Entrez GeneID：838

Swissprot：P51878

WB Predicted band size：49.7kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：This CASP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-191 amino acids from the Central region of human CASP5.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：1/2000

宿主：Rabbit