名称：Amyloid β A4 (Phospho-Thr743/668)

别名：A4; AD1; APP; APPI; Beta-amyloid protein 42

Pathway：Notch signaling pathway

Modified：Phosphorylated

Targets：FDA approved drug target related

描述

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity By similarity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Ming-Sum Lee J. Cell Biol., Oct 2003; 163: 83Tadashi Nakaya and Toshiharu Suzuki Genes Cells, Jun 2006; 11: 633 - 645Keun-A Chang, Mol. Cell. Biol., Jun 2006; 26: 4327 篓C 4338Thor D. Stein J. Neurosci., Sep 2004; 24: 7707 - 7717

Specification

Entrez GeneID：351;

Swissprot：P05067

Gene Accession：Swiss-Prot#: P05067; NCBI Gene#: 351; NCBI Protein#: NP_000475.1.

WB Predicted band size：140kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of threonine743 /668 (A-V-T(p)-P-E) derived from Human Amyloid β A4.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit