名称：a-Synuclein(Phospho-Tyr125)

别名：NACP; SYN; SYUA; alpha-synuclein;

Modified：Phosphorylated

Targets：Disease

描述

SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons

文献

Takahashi T, et al. J Biol Chem 2003 Oct 24; 278(43): 42225-33

Ahn BH, et al. J Biol Chem 2002 Apr 05; 277(14): 12334-42

Negro A, et al. FASEB J 2002 Feb; 16(2): 210-2

Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119.

Specification

Entrez GeneID：6622;

Swissprot：P37840

Gene Accession：Swiss-Prot: P37840NCBI Protein: NP_000336.1

WB Predicted band size：18kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Peptide sequence around phosphorylation site of tyrosine 125 (E-A-Y(p)-E-M) derived from Human a-Synuclein.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IF

WB：1/500-1/1000

ICC：1/100-1/200

宿主：Rabbit