名称：eIF4E(Phospho-Ser209)

别名：mRNA cap-binding protein; eIF-4F 25 kDa subunit;

Pathway：PI3K-Akt signaling pathway

Pathway：mTOR signaling pathway

Modified：Phosphorylated

描述

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.

文献

Li BD, et al. (1998) Ann Surg; 227(5): 756-763

Altmann M, et al. (1989) Nucleic Acids Res; 17(18): 7520

De Gregorio E, et al. (2001) RNA; 7(1): 106-113

Gu W, et al. (2004) Nucleic Acids Res; 32(15): 4448-4461

Specification

Entrez GeneID：1977;

Swissprot：P06730

Gene Accession：Swiss-Prot: P06730NCBI Protein: NP_001124150.1

WB Predicted band size：25kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Peptide sequence around phosphorylation site of serine 209 (S-G-S(p)-T-T) derived from Human eIF4E.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit