名称：BRCA1(Phospho-Ser1423)

别名：RNF53

Pathway：PI3K-Akt signaling pathway

Modified：Phosphorylated

Targets：Disease

描述

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation

文献

Kim ST, et al. (2002) Genes Dev; 16(5): 560-570Arlt MF, et al. (2004) Mol Cell Biol; 24(15): 6701-6709Zhang J, et al. (2004) Mol Cell Biol; 24(2): 708-718Greenberg RA, et al. (2006) Genes Dev; 20(1): 34-46Tibbetts RS, et al. (2000) Genes Dev; 14(23): 2989-3002

Specification

Entrez GeneID：672;

Swissprot：P38398

Gene Accession：Swiss-Prot: P38398NCBI Protein: NP_009225.1

WB Predicted band size：220kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Peptide sequence around phosphorylation site of serine 1423 (H-G-S(p)-Q-P) derived from Human BRCA1.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC

WB：1/500-1/1000

IHC：1/50-1/100

宿主：Rabbit