名称：TrkB(Phospho-Tyr515)

别名：BDNF/NT-3 growth factors receptor precursor; GP145-TrkB; GP145-TrkB/GP95-TrkB; NTRK2; Trk-B

Pathway：PI3K-Akt signaling pathway

Pathway：MAPK signaling pathway

Pathway：Hippo signaling pathway

Modified：Phosphorylated

Targets：FDA approved drug target related

描述

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

文献

Woronowicz A, et al. Glycobiology. 2007 Jan;17(1):10-24.Mojsilovic-Petrovic J, et al. J Neurosci. 2006 Sep 6;26(36):9250-63.Lewis MA, et al. Mol Pharmacol. 2006 Apr;69(4):1396-404.Cai D, et al. Physiol Genomics. 2006 Feb 14;24(3):191-7.

Specification

Entrez GeneID：4915;

Swissprot：Q16620

Gene Accession：Swiss-Prot: Q16620NCBI Protein: NP_001007098.1

WB Predicted band size：140kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of tyrosine 515 (P-Q-Y(p)-F-G) derived from Human TrkB.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：IF

ICC：1/100-1/200

宿主：Rabbit