名称：LATS1/2 (Phospho-Thr1079/1041)

别名：WARTS; Large tumor suppressor 1; EC 2.7.11.1;

Pathway：Hippo signaling pathway

Modified：Phosphorylated

描述

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Tao W., Nat. Genet. 21:177-181(1999)Nishiyama Y., FEBS Lett. 459:159-165(1999)The MGC Project Team, Genome Res. 14:2121-2127(2004).

Specification

Entrez GeneID：9113;

Swissprot：O95835

Gene Accession：Swiss-Prot#: O95835/Q9NRM7; NCBI Gene#: 9113/26524; NCBI Protein#: NP_004681.1.

WB Predicted band size：126kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse

免疫原：Peptide sequence around phosphorylation site of threonine 1079/1041 (E-F-T(p)-F-R) derived from Human LATS1/2 .

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：IHC

IHC：1/50-1/100

宿主：Rabbit