名称：ADAM 17 (Phospho-Thr735)

别名：CSVP, TACE, NISBD, ADAM18, CD156B

Pathway：Notch signaling pathway

Modified：Phosphorylated

描述

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway.

Specification

Entrez GeneID：6868;

Swissprot：P78536

Gene Accession：Swiss-Prot#: P78536; NCBI Gene#: 6868; NCBI Protein#: NP_003174.3

WB Predicted band size：93kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of Threonine 735

(P-Q-T(p)-P-G) derived from Human ADAM 17.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：1/500-1/1000

宿主：Rabbit