名称：Pim-1 (Phospho-Tyr309)

别名：PIM-1; Proto-oncogene serine/threonine-protein kinase pim-1; EC 2.7.11.1;

Modified：Phosphorylated

描述

Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis.

文献

Selten G., Cell 46:603-611(1986)

Saris C.J., EMBO J. 10:655-664(1991)

Maita H., Eur. J. Biochem. 267:5168-5178(2000).

Specification

Entrez GeneID：5292;

Swissprot：P11309

Gene Accession：Swiss-Prot#: P11309; NCBI Gene#: 5292; NCBI Protein#: NP_001230115.1

WB Predicted band size：45kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of tyrosine 309(H-R-Y(p)-H-G) derived from Human Pim-1.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：1/500-1/1000

宿主：Rabbit