名称：ATM(Phospho-Ser1981)

别名：Ataxia telangiectasia mutated homolog; Ataxia telangiectasia mutated; kinase ATM

Modified：Phosphorylated

Targets：Disease

描述

ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene.

文献

Gupta A. et al. (2005) Mol Cell Biol. 25(12): 5292-5305.

Bernstein JL. et al. (2002) Breast Cancer Res. 4(6): 249-252.

Silverman J. et al. (2004) Genes Dev. 18(17): 2108-2119.

Nakada D. et al. (2003) Nucleic Acids Res. 31(6): 1715-1724.

Specification

Entrez GeneID：472;

Swissprot：Q13315

Gene Accession：Swiss-Prot: Q13315NCBI Protein: NP_000042.3

WB Predicted band size：350kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Peptide sequence around phosphorylation site of serine 1981 (E-G-S(p)-Q-S) derived from Human ATM.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC

WB：1/500-1/1000

IHC：1/50-1/100

宿主：Rabbit