名称：PKCth(Phospho-Ser676)

别名：KPCT; PKC-theta; PKCQ; PRKCQ; PRKCT

Modified：Phosphorylated

描述

This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production.

文献

Kristof Van Kolen, et al. (2006) FEBS J ; 273: 1843 - 1854.

Martin Villalba, et al. (2002) J. Cell Biol ; 157: 253.

Jie Zhang, et al. (2004) J. Biol. Chem ; 279: 22118 - 22123.

Castro AF, et al. (1998) Am J Physiol Cell Physiol; 275: C113 - C119.

Specification

Entrez GeneID：5588;

Swissprot：Q04759

Gene Accession：Swiss-Prot: Q04759NCBI Protein: NP_006248.1

WB Predicted band size：80kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of serine 676 (R-L-S(p)-F-A) derived from Human PKCth.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit