名称：p7S6 Kinase(Phospho-Thr421)

别名：KS6B1; P70-S6K; RPS6KB1; S6K;

Pathway：PI3K-Akt signaling pathway

Pathway：mTOR signaling pathway

Modified：Phosphorylated

描述

Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation.

文献

Xiao-Feng, et al. (2003) Le1 30 Volume 22: 484-497An WL, et al. (2003) Am J Pathol. 163(2): 591-607.Le XF, et al. (2003) Oncogene.22(4): 484-97

Specification

Entrez GeneID：6198;

Swissprot：P23443

Gene Accession：Swiss-Prot: P23443NCBI Protein: NP_003152.1

WB Predicted band size：70 85 kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of threonine 421 (P-R-T(p)-P-V) derived from Human p70 S6 Kinase.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit