名称：Kir6.2 (Phospho-Thr224)

别名：ATP-sensitive inward rectifier potassium channel 11; IKATP; IRK11; Inward rectifier K channel Kir6.2; KCNJ11; Potassium channel; inwardly rectifying; subfamily J; member 11

Modified：Phosphorylated

Targets：FDA approved drug target related

描述

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium By similarity. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

Specification

Entrez GeneID：3767;

Swissprot：Q14654

Gene Accession：Swiss-Prot#:Q14654;NCBI Gene#:3767

WB Predicted band size：40kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse

免疫原：Peptide sequence around phosphorylation site of threonine 224 (K-T-TP-S-P) derived from Human Kir6.2.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IF

WB：1/500-1/3000

ICC：1/100-1/500

宿主：Rabbit