名称：BAD (Phospho-Ser91/128)

别名：BAD; BBC6; BCL2L8; Bcl- XL/Bcl-2 associated death promoter;

Pathway：PI3K-Akt signaling pathway

Modified：Phosphorylated

描述

The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform

文献

Wang H.-G., Cell 87:629-638(1996)

Ottilie S., J. Biol. Chem. 272:30866-30872(1997)

The MGC Project Team, Genome Res. 14:2121-2127(2004).

Specification

Entrez GeneID：572;

Swissprot：Q92934

Gene Accession：Swiss-Prot#: Q92934; NCBI Gene#: 572; NCBI Protein#: NP_004313.1.

WB Predicted band size：22kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of Serine 128 (E-L-S(p)-P-F) derived from Mouse BAD.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC

WB：1/500-1/1000

IHC：1/50-1/100

宿主：Rabbit