名称：GSK3α/β(Phospho-Tyr279/216)

别名：Factor A; GSK-3 alpha/beta; kinase GSK3-alpha/beta

Pathway：Wnt signaling pathway

Modified：Phosphorylated

描述

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.

文献

Chin PC, et al. Brain Res Mol Brain Res 2005 Jun 13; 137(1-2): 193-201

Takahashi-Yanaga F, et al. Biochem Biophys Res Commun 2004 Apr 02; 316(2): 411-415

Fan G, et al. J Biol Chem 2003 Dec 26; 278(52): 52432-52436

Liao X, et al. Mol Cancer Ther 2003 Nov; 2(11): 1215-1222

Specification

Entrez GeneID：2931;

Swissprot：P49840

Gene Accession：Swiss-Prot:P49840Gene ID:2931

WB Predicted band size：46, 51kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of tyrosine 279/216 (V-S-Y(p)-I-C) derived from Human GSK3α/β.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit