名称：P38 MAPK(Phospho-Tyr182)

别名：MAPK2; MAPKAPK-2; MAPKAPK2

Pathway：TGF-beta signaling pathway

Pathway：MAPK signaling pathway

Modified：Phosphorylated

描述

Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.

文献

Ming Zheng, et al.(2005) The FASEB Journal. 19: 109-111

Bernt van den et al.(2001) Blink Immunology, 166: 582-587

Arshad Rahman, et al. (2004) Am J Physiol Lung Cell Mol Physiol 287: L1017-L1024

Osamu Yoshino, et al. (2003) Endocrinology & Metabolism Vol. 88: 2236-2241

Specification

Entrez GeneID：1432;

Swissprot：Q16539

Gene Accession：Swiss-Prot: Q16539NCBI Protein: NP _001306.1

WB Predicted band size：43kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of tyrosine 182 (T-G-Y(p)-V-A) derived from Human P38 MAPK.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC

WB：1/500-1/1000

IHC：1/50-1/100

宿主：Rabbit