名称：GR (Phospho-Ser203)

别名：GCCR, GCR, GR, GRL

Modified：Phosphorylated

Targets：FDA approved drug target related

描述

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.

Specification

Entrez GeneID：2908;

Swissprot：P04150

Gene Accession：Swiss-Prot#: P04150; NCBI Gene#: 2908; NCBI Protein#: NP_000167.1

WB Predicted band size：86kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Peptide sequence around phosphorylation site of Serine 203

(S-G-S(p)-P-G) derived from Human GR.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：1/500-1/1000

宿主：Rabbit