名称：Epo-R (Phospho-Tyr368)

别名：EPO R; EPO-R; epor;

Pathway：PI3K-Akt signaling pathway

Modified：Phosphorylated

Targets：Disease

描述

Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.Funakoshi-Tago M, et al. (2010) J Biol Chem 285, 5296-307 Sulahian R, Cleaver O, Huang LJ (2009) Blood 113, 5287-97 Zhang YL, et al. (2009) Mol Cell 33, 266-74

Specification

Entrez GeneID：2057;

Swissprot：P19235

Gene Accession：Swiss-Prot#: P19235; NCBI Gene#: 2057; NCBI Protein#: NP_000112.1

WB Predicted band size：55kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse

免疫原：Peptide sequence around phosphorylation site of Tyrosine 368 (D-T-Y(p)-L-V) derived from Human Epo-R.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：1/500-1/1000

宿主：Rabbit