名称：STAT3(Phospho-Tyr705)

别名：APRF; Acute-phase response factor; HIES

Pathway：Jak-STAT signaling pathway

Modified：Phosphorylated

Targets：Disease

描述

Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

文献

Fan G, et al. (2003) J Biol Chem. 278(52): 52432-52436.

Barry FA, et al. (2003) FEBS Lett. 553(1-2): 173-178.

Welsh, et al. (1996) Trends Cell Biol. 6: 274-279.

Srivastava A K, et al. (1998) Mol Cell Biochem. 182: 135-141.

Specification

Entrez GeneID：6774;

Swissprot：P40763

Gene Accession：Swiss-Prot: P40763NCBI Protein: NP_003141.2

WB Predicted band size：88kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of tyrosine 705 (A-P-Y(p)-L-K) derived from Human STAT3.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit