名称：BCL-2(Phospho-Ser70)

别名：Bcl-2; PPP1R50

Pathway：TGF-beta signaling pathway

Pathway：PI3K-Akt signaling pathway

Modified：Phosphorylated

Targets：FDA approved drug target related

描述

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

Specification

Entrez GeneID：596;

Swissprot：P10415

Gene Accession：Swiss-Prot: P10415; NCBI Gene ID: 596; NCBI mRNA: NM_000633.2; NCBI Protein: NP_000624.2

WB Predicted band size：26kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Peptide sequence around phosphorylation site of serine 70(R-T-S(p)-P-L) derived from Human BCL-2.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：IHC

IHC：1/50-1/100

宿主：Rabbit