名称：ALK (Phospho-Tyr1096)

别名：ALK tyrosine kinase receptor; anaplastic lymphoma kinase; anaplastic lymphoma kinase (Ki-1); CD246; EC 2.7.10.1; kinase ALK

Modified：Phosphorylated

Targets：FDA approved drug target related

描述

The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. Morris S.W., Oncogene 14:2175-2188(1997)Morris S.W., Oncogene 15:2883-2883(1997)Iwahara T., Oncogene 14:439-449(1997).

Specification

Entrez GeneID：238;

Swissprot：Q9UM73

Gene Accession：Swiss-Prot#: Q9UM73; NCBI Gene#: 238; NCBI Protein#: NP_004295.2

WB Predicted band size：176kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Peptide sequence around phosphorylation site of tyrosine 1096 (P-N-Y(p)-C-F) derived from Human ALK.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：IHC

IHC：1/50-1/100

宿主：Rabbit