名称：ILK (Phospho-Ser246)

别名：ILK1; p59ILK; kinase ILK;

Modified：Phosphorylated

描述

Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.Hannigan G.E., Nature 379:91-96(1996)Janji B., Oncogene 19:3069-3077(2000)Tadic B., Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.

Specification

Entrez GeneID：3611;

Swissprot：Q13418

Gene Accession：Swiss-Prot#: Q13418; NCBI Gene#: 3611; NCBI Protein#: NP_001014794.1.

WB Predicted band size：51kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Peptide sequence around phosphorylation site of Serine 246(I-F-S(p)-H-P) derived from Human ILK.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：IHC

IHC：1/50-1/100

宿主：Rabbit