名称：EGFR(Phospho-Tyr1172)

别名：ERBB1; Receptor protein-tyrosine kinase ErbB-1; kinase EGFR

Pathway：TGF-beta signaling pathway

Pathway：PI3K-Akt signaling pathway

Pathway：MAPK signaling pathway

Pathway：Jak-STAT signaling pathway

Pathway：Hippo signaling pathway

Modified：Phosphorylated

Targets：Disease

描述

Receptor for EGF, but also for other members of the EGF family, as TGF-a, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.

文献

Noguchi T, et al. (1994) Mol Cell Biol 14(10): 6674-6682Doherty JK, et al. (1999) Proc Natl Acad Sci U S A 96(19): 10869-10874Kanner SB, et al. (1991) Mol Cell Biol 11(2): 713-720Wu TT, et al. (1998) Mol Biol Cell 9(7): 1661-1674

Specification

Entrez GeneID：1956;

Swissprot：P00533

Gene Accession：Swiss-Prot: P00533NCBI Protein: NP_005219.2

WB Predicted band size：175kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of tyrosine 1172 (P-D-Y(p)-Q-Q) derived from Human EGFR.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC

WB：1/500-1/1000

IHC：1/50-1/100

宿主：Rabbit