名称：FKHR(Phospho-Ser319)

别名：FOXO1

Modified：Phosphorylated

描述

FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14

文献

Rena G, et al. (2002) EMBO J 21(9): 2263-2271.

Woods YL, et al. (2001) Biochem J355(Pt 3): 597-607.

Rena G, et al. (2001) Biochem J 354(Pt 3): 605-612.

Specification

Entrez GeneID：2308;

Swissprot：Q12778

Gene Accession：Swiss-Prot: Q12778NCBI Protein: NP_002006.2

WB Predicted band size：78-82 kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of serine 319 (T-S-S(p)-N-A) derived from Human FKHR/FOXO1A.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit