名称：FADD (Phospho-Ser191)

别名：MORT1 ; FAS-associating death domain-containing protein; Mediator of receptor induced toxicity;

Modified：Phosphorylated

描述

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development

文献

Sugano S., Nat. Genet. 36:40-45(2004)

Farmer A., Submitted (MAY-2003)

Venter J.C., Submitted (JUL-2005).

Specification

Entrez GeneID：14082;

Swissprot：Q61160

Gene Accession：Swiss-Prot#: Q61160; NCBI Gene#: 14082; NCBI Protein#: NP_034305.1.

WB Predicted band size：25kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse

免疫原：Peptide sequence around phosphorylation site of Serine191(N-M-S(p)-P-V) derived from Mouse FADD.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC

WB：1/500-1/1000

IHC：1/50-1/100

宿主：Rabbit