名称：FAK(Phospho-Tyr397)

别名：FAK; FAK1; PTK2

Pathway：PI3K-Akt signaling pathway

Modified：Phosphorylated

描述

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

文献

Matsuya M.et.al. (1998)J. Biol. Chem. 273:1003-1014

Fujita H.et.al. (1998)J. Biol. Chem. 273:26516-26521

Le Romancer M.et.al. (2008)Mol. Cell 31:212-221

Specification

Entrez GeneID：5747;

Swissprot：Q05397

Gene Accession：Swiss-Prot: Q05397NCBI Protein: NP_001186578.1

WB Predicted band size：125kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of tyrosine 397(D-D-Y(p)-A-E)derived from Human FAK.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC

WB：1/500-1/1000

IHC：1/50-1/100

宿主：Rabbit