名称：Caspase 9 (Phospho-Thr125)

别名：APAF-3; MCH6; RNCASP9; CASP-9; ICE-LAP6

Pathway：PI3K-Akt signaling pathway

Modified：Phosphorylated

描述

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

文献

Duan H., J. Biol. Chem. 271:16720-16724(1996)Srinivasula S.M., J. Biol. Chem. 271:27099-27106(1996)Hadano S., Mamm. Genome 10:757-760(1999)

Specification

Entrez GeneID：842;

Swissprot：P55211

Gene Accession：Swiss-Prot#: P55211; NCBI Gene#: 842; NCBI Protein#: NP_001220.2.

WB Predicted band size：47kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Peptide sequence around phosphorylation site of threonine 125 (P-E-T(p)-P-R) derived from Human Caspase 9.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC

WB：1/500-1/1000

IHC：1/50-1/100

宿主：Rabbit