名称：ATF1 (Phospho-Ser63)

别名：ATF1; Activating transcription factor 1; Cyclic-AMP-dependent transcription factor ATF-1; TCR-ATF1; TREB36 protein

Modified：Phosphorylated

描述

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. Mackenzie KF, et al. (2013) J Immunol 190, 565-77 Dickinson RJ, et al. (2011) J Biol Chem 286, 38018-26 Wang J, Zhou JY, Wu GS (2011) J Biol Chem 286, 22384-92

Specification

Entrez GeneID：466;

Swissprot：P18846

Gene Accession：Swiss-Prot#: P18846; NCBI Gene#: 466; NCBI Protein#: NP_005162.1

WB Predicted band size：29kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse

免疫原：Peptide sequence around phosphorylation site of serine 63(R-P-S(p)-Y-R) derived from Human ATF1 .

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB

WB：1/500-1/1000

宿主：Rabbit