名称：MEK1(Phospho-Ser221)

别名：ERK activator kinase 1; MAP kinase kinase 1; MAP2K1; MAPK/ERK kinase 1; MAPKK 1

Pathway：TGF-beta signaling pathway

Pathway：PI3K-Akt signaling pathway

Pathway：mTOR signaling pathway

Pathway：MAPK signaling pathway

Pathway：Jak-STAT signaling pathway

Modified：Phosphorylated

Targets：Disease

描述

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.

文献

Zebisch A, et al. (2006) Cancer Res; 66(7): 3401-8.

Luciano BS, et al. (2006)J Biol Chem; 279(50): 52117-23.

Wang X, et al. (2003) Oncogene; 22(1): 109-16.

Gopalbhai K, et al. (2003) J Biol Chem; 278(10): 8118-25.

Ling MT, et al. (2002)Oncogene; 21(55): 8498-505.

Specification

Entrez GeneID：5604;

Swissprot：Q02750

Gene Accession：Swiss-Prot: Q02750NCBI Protein: NP_002746.1

WB Predicted band size：45kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of serine 221 (A-N-S(p)-F-V) derived from Human MEK1.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/50-1/100

ICC：1/100-1/200

宿主：Rabbit