名称：IKK-γ (Phospho-Ser376)

别名：FIP3; IKBKG; IKKAP1; IKKG; NF-kappaB

Pathway：PI3K-Akt signaling pathway

Pathway：MAPK signaling pathway

Modified：Phosphorylated

Targets：Disease

描述

Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males. In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation. Li Y., Proc. Natl. Acad. Sci. U.S.A. 96:1042-1047(1999)Jin D.-Y., J. Biomed. Sci. 6:115-120(1999)Rothwarf D.M., Nature 395:297-300(1998).

Specification

Entrez GeneID：8517;

Swissprot：Q9Y6K9

Gene Accession：Swiss-Prot#: Q9Y6K9; NCBI Gene#: 8517; NCBI Protein#: NP_001093327.1.

WB Predicted band size：48kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Peptide sequence around phosphorylation site of Serine 376(Y-L-S(p)-S-P) derived from Human IKK-γ.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：IHC

IHC：1/50-1/100

宿主：Rabbit