名称：ATF-2 (Phospho-Ser472)

别名：Activating 2; ATF2; cAMP response element binding protein CRE- BP1; CREB2; HB16

Pathway：TGF-beta signaling pathway

Pathway：PI3K-Akt signaling pathway

Pathway：MAPK signaling pathway

Modified：Phosphorylated

描述

Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.

文献

Maekawa T., EMBO J. 8:2023-2028(1989)

Yang L., J. Immunol. 158:2522-2525(1997)

Kara C.J., Mol. Cell. Biol. 10:1347-1357(1990).

Specification

Entrez GeneID：1386;

Swissprot：P15336

Gene Accession：Swiss-Prot#: P15336; NCBI Gene#: 1386; NCBI Protein#: NP_001243019.1.

WB Predicted band size：54kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human

免疫原：Peptide sequence around phosphorylation site of Serine 472 (A-L-S(p)-Q-I) derived from Human ATF-2.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：IHC

IHC：1/50-1/100

宿主：Rabbit