名称：PI3 Kinase p85/p55 (phospho-Tyr467/199)

别名：p85, AGM7, p85-ALPHA, p55, p55-GAMMA, PIK3R1

Pathway：TGF-beta signaling pathway

Pathway：PI3K-Akt signaling pathway

Pathway：Jak-STAT signaling pathway

Modified：Phosphorylated

Targets：Disease

描述

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1./Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.

文献

Stoyanov, B. et al. (1995) Science 269, 690-3.

Simpson, L. and Parsons, R. (2001) Exp Cell Res 264, 29-41.

Neri, L.M. et al. (2002) Biochim Biophys Acta 1584, 73-80.

Specification

Entrez GeneID：5295;

Swissprot：P27986

Gene Accession：Swiss-Prot:P27986Gene ID:5295

WB Predicted band size：55,85kDa

Host/Isotype：Rabbit IgG

Antibody Type：Primary antibody

Storage：Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity：Human,Mouse,Rat

免疫原：Peptide sequence around phosphorylation site of tyrosine 467 (L-Y(p)-E-E-Y) derived from Human PI3 Kinase p85/p55.

Formulation：Purified antibody in PBS with 0.05% sodium azide.

Application

Application：WB,IHC,IF

WB：1/500-1/1000

IHC：1/100-1/300

ICC：1/100-1/500

宿主：Rabbit